What is methotrexate?Methotrexate is a favored drug among rheumatologists for the treatment of RA. It interferes with a metabolic pathway called the folic acid pathway.
How does it work?It interrupts the cycle of certain cells important to the immune system.
What is the usual dose?Patients with RA usually begin with a low dose, usually 7.5 milligrams per week, followed by a gradual increase to 25 milligrams per week. Some patients can even tolerate higher doses. It is really up to your doctor. It should be taken with 1 to 4 milligrams of folic acid daily, as this vitamin limits the poisonous effects of the drug.
When does it start to work?It usually takes effect within four to six weeks.Traditional Therapy: Drugs, Surgery, and Rehabilitation Therapy
What side effects should I watch out for?Some of the most common side effects of this drug include sores in the mouth, lung congestion, nausea, abdominal cramps, loss of appetite, and, although rarely, infections. Fortunately, these are not common, and most are reversible when caught early. In addition, new nodules similar to rheumatoid nodules form in some patients. Your doctor can treat these nodules with a drug called colchicine.*33/141/5*

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